What is the difference between multaq and amiodarone

Whether this tradeoff between safety and efficacy is clinically important remains to be seen. Piccini JP et al. Comparative efficacy of dronedarone and amiodarone for the maintenance of sinus rhythm in patients with atrial fibrillation. J Am Coll Cardiol Sep 15; Comment In this exploratory analysis, dronedarone was safer but also less effective at maintaining sinus rhythm than was amiodarone.

Citation s : Piccini JP et al. The study duration was six months. Heart rhythm assessment was performed by lead ECGs during scheduled clinic visits. The main endpoints included recurrence of atrial fibrillation, premature study discontinuation for lack of efficacy, and premature drug discontinuation for intolerance. Other endpoints included unsuccessful electrical cardioversion and no spontaneous cardioversion with no electrical cardioversion.

The study enrolled and randomized patients. The most common cardiovascular diagnosis was hypertension Amiodarone appeared to be more effective than dronedarone. Side effects were more common during amiodarone treatment. Thyroid disorders, neurologic events, and skin reactions were all more common with amiodarone.

Diarrhea, nausea, and vomiting were more frequently seen in the dronedarone group. Hepatic enzyme elevations were seen with a similar frequency in both groups. Both groups experienced a moderate increase in creatinine plasma levels. There were more supratherapeutic INR levels in the amiodarone group.

A higher incidence of hemorrhagic events was also seen in amiodarone. No pulmonary toxicity was noted in either group in this short-term study. The authors conclude that dronedarone was less effective than amiodarone for preventing AF recurrence but had a better safety profile due to a reduced frequency of thyroid and neurologic adverse reactions and a lessened potential for interaction with oral anticoagulants.

A normal logistic regression model incorporating all trial evidence found amiodarone superior to dronedarone OR: 0. In contrast, these models also found a trend toward greater all-cause mortality OR: 1.

Conclusions: Dronedarone is less effective than amiodarone for the maintenance of sinus rhythm, but has fewer adverse effects. For every 1, patients treated with dronedarone instead of amiodarone, we estimate approximately more recurrences of AF in exchange for 9.