How does tissue fluid formed

Don't have an account? Sign in via your Institution. You could not be signed in, please check and try again. Sign in with your library card Please enter your library card number. Related Content Related Overviews ultrafiltration osmosis. Show Summary Details Overview tissue fluid. All rights reserved. It constitutes the internal environment of the body, which surrounds tissue cells. It is obvious that anything that increases the capillary permeability will increase the amount of tissue fluid formed.

Regarding blood pressure and osmotic pressure, it is known that at the arterial end of capillaries, the average blood pressure is about 32 mm of Hg and at the venous end, 10 mm of Hg. The colloidal osmotic pressure at both ends is same 25 mm of Hg on the average. At the arterial end, the net filtration pressure which is the difference between the two is 7 mm of Hg towards the tissue interstitial fluid.

At the venous end due to fall in blood or hydrostatic pressure, the filtration pressure is 15 mm of Hg to the opposite side, i. The amount of tissue fluid formed from the tissue cells depends upon the degree of metabolic activity of the cells.

Tissue cells produce water as an end product of metabolism. This metabolic water is added to the already existing tissue fluid. More the degree of activity more will be the metabolic water formed and consequently the amount of tissue fluid will increase.

It is very difficult to obtain a pure sample of tissue fluid; hence, its exact composition is not known. It is believed that its composition is same as that of lymph, excepting that its protein content is negligible; and as such, its colloidal osmotic pressure is very low. The composition and volume of tissue fluid is regulated by constant interchange with blood and lymph. It has been mentioned above that filtration of tissue fluid takes place at the arterial end of the capillaries.

At the venous end of the capillary the blood pressure is very low—about 10 mm of Hg and the colloidal osmotic pressure is much higher. These two factors help in drawing away just as much fluid comes out from the arterial side. As we know that water content of tissue fluid is derived from two sources—blood and tissue cells. The amount of water that goes out of blood is drawn in again at the venous side of the capillaries.

But vascular capillaries cannot draw away the amount of metabolic water formed by the tissue cells. It is for the drainage of this excess water that the lymphatic system has developed. Thus it will be seen that blood and lymph remain as if on two sides of tissue fluid and try to keep it constant in volume and composition by continuous interchange. Specific gravity of the tissue fluid is about 1. It may contain a few erythrocytes.

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